Geranylgeranylacetone Ameliorates Inflammatory Response to Lipopolysaccharide (LPS) in Murine Macrophages: Inhibition of LPS Binding to The Cell Surface

We investigated whether pretreatment with geranylgeranylacetone (GGA), a potent heat shock protein (HSP) inducer, could inhibit proinflammatory cytokine liberation and nitric oxide (NO) production in lipopolysaccharide (LPS)-treated murine macrophages. The levels of NO and tumor necrosis factor-α (T...

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Hauptverfasser: Mochida, Shinsuke, Matsura, Tatsuya, Yamashita, Atsushi, Horie, Shunsuke, Ohata, Shuzo, Kusumoto, Chiaki, Nishida, Tadashi, Minami, Yukari, Inagaki, Yoshimi, Ishibe, Yuichi, Nakada, Junya, Ohta, Yoshiji, Yamada, Kazuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: the Society for Free Radical Research Japan 2007
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2170953/
https://ncbi.nlm.nih.gov/pubmed/18193105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3164/jcbn.2007016
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