Pretarget radiotherapy with an anti-CD25 antibody-streptavidin fusion protein was effective in therapy of leukemia/lymphoma xenografts

Although radioimmunotherapy with radiolabeled intact monoclonal antibodies has demonstrated efficacy in the treatment of lymphoma, it provides low tumor-to-normal-tissue radionuclide target ratios and unwanted prolonged radiation exposure to the bone marrow. To overcome these obstacles, the administ...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhang, Meili, Zhang, Zhuo, Garmestani, Kayhan, Schultz, Jody, Axworthy, Donald B., Goldman, Carolyn K., Brechbiel, Martin W., Carrasquillo, Jorge A., Waldmann, Thomas A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 2003
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC149929/
https://ncbi.nlm.nih.gov/pubmed/12569172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0437788100
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