STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of STAT3 in innate immunity

Signal transducer and activator of transcription 3 (STAT3) is a key transcriptional mediator for many cytokines and is essential for normal embryonic development. We have generated a unique strain of mice with tissue-specific disruption of STAT3 in bone marrow cells during hematopoiesis. This specif...

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Detalhes bibliográficos
Main Authors: Welte, Thomas, Zhang, Samuel S. M., Wang, Tian, Zhang, Zhiyuan, Hesslein, David G. T., Yin, Zhinan, Kano, Arihiro, Iwamoto, Yoshiki, Li, En, Craft, Joseph E., Bothwell, Alfred L. M., Fikrig, Erol, Koni, Pandelakis A., Flavell, Richard A., Fu, Xin-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC149927/
https://ncbi.nlm.nih.gov/pubmed/12571365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0237137100
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