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Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC

Nonthymic epithelial cells were compared with thymic epithelial cells for their role in T cell repertoire selection. Tetraparental aggregation chimeras were generated from T and B cell-deficient mice (H-2(d) SCID or H-2(b) Rag−/−) and thymus-deficient nude mice (H-2(b) or H-2(d)). These tetraparenta...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Martinic, Marianne M., Rülicke, Thomas, Althage, Alana, Odermatt, Bernhard, Höchli, Matthias, Lamarre, Alain, Dumrese, Tilman, Speiser, Daniel E., Kyburz, Diego, Hengartner, Hans, Zinkernagel, Rolf M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149924/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12574503/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.252641399
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