Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by β-d-glucosylceramide synthase deficiency

Va14Ja18 natural T (NKT) cells play an immunoregulatory role, which is controlled by a self glycolipid(s) presented by CD1d. Although the synthetic antigen α-D-galactosylceramide (α-D-GalCer) stimulates all Va14Ja18 NKT cells, α-anomeric D-glycosylceramides are currently unknown in mammals. We have...

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Detalhes bibliográficos
Main Authors: Stanic, Aleksandar K., De Silva, A. Dharshan, Park, Jang-June, Sriram, Venkataraman, Ichikawa, Shinichi, Hirabyashi, Yoshio, Hayakawa, Kyoko, Van Kaer, Luc, Brutkiewicz, Randy R., Joyce, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC149922/
https://ncbi.nlm.nih.gov/pubmed/12576547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0430327100
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