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Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations
mtDNA mutations occur in a wide variety of degenerative diseases and cancer. mtDNA seems to be more susceptible to DNA damage and consequently sustains higher rates of mutation than does nuclear DNA (nDNA). Many of the somatic mtDNA mutations in human cancers are located in the displacement loop (D-...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC149920/ https://ncbi.nlm.nih.gov/pubmed/12578990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0437910100 |
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