Regulation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and mitochondrial function by MEF2 and HDAC5

The myocyte enhancer factor-2 (MEF2) transcription factor regulates muscle development and calcium-dependent gene expression. MEF2 activity is repressed by class II histone deacetylases (HDACs), which dissociate from MEF2 when phosphorylated on two serine residues in response to calcium signaling. T...

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Autores principales: Czubryt, Michael P., McAnally, John, Fishman, Glenn I., Olson, Eric N.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2003
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC149898/
https://ncbi.nlm.nih.gov/pubmed/12578979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0337639100
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