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Designed to be stable: Crystal structure of a consensus ankyrin repeat protein

Ankyrin repeat (AR) proteins mediate innumerable protein–protein interactions in virtually all phyla. This finding suggested the use of AR proteins as designed binding molecules. Based on sequence and structural analyses, we designed a consensus AR with fixed framework and randomized interacting res...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kohl, Andreas, Binz, H. Kaspar, Forrer, Patrik, Stumpp, Michael T., Plückthun, Andreas, Grütter, Markus G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149896/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12566564/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0337680100
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