Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors

The herpes simplex virus 1 (HSV-1) replicative cycle begins by binding of the viral activator, VP16, to a set of sequences in the immediate-early (IE) gene promoters. With the aim of inhibiting this cycle, we have constructed a number of synthetic zinc-finger DNA-binding peptides by using recently r...

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Hlavní autoři: Papworth, Monika, Moore, Michael, Isalan, Mark, Minczuk, Michal, Choo, Yen, Klug, Aaron
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2003
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC149882/
https://ncbi.nlm.nih.gov/pubmed/12574501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252773399
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