A Single Amino Acid Substitution in Herpes Simplex Virus Type 1 VP16 Inhibits Binding to the Virion Host Shutoff Protein and Is Incompatible with Virus Growth

In addition to its well-established role in the activation of herpes simplex virus immediate-early gene transcription, VP16 interacts with and downregulates the function of the virion host shutoff protein (vhs), thereby attenuating vhs-mediated destruction of viral mRNAs and translational arrest at...

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Bibliographic Details
Main Authors: Knez, J., Bilan, P. T., Capone, J. P.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC149789/
https://ncbi.nlm.nih.gov/pubmed/12584313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.5.2892-2902.2003
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