Mumps Virus Decreases Testosterone Production and Gamma Interferon-Induced Protein 10 Secretion by Human Leydig Cells

Mumps virus is responsible for sterility. Here, we show that the mumps virus infects Leydig cells in vitro and totally inhibits testosterone secretion and that ribavirin in mumps virus-infected Leydig cell cultures completely restores testosterone production. Moreover, we show that gamma interferon-...

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Autores principales: Le Goffic, Ronan, Mouchel, Thomas, Ruffault, Annick, Patard, Jean-Jacques, Jégou, Bernard, Samson, Michel
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC149733/
https://ncbi.nlm.nih.gov/pubmed/12584353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.5.3297-3300.2003
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