Mumps Virus Decreases Testosterone Production and Gamma Interferon-Induced Protein 10 Secretion by Human Leydig Cells

Mumps virus is responsible for sterility. Here, we show that the mumps virus infects Leydig cells in vitro and totally inhibits testosterone secretion and that ribavirin in mumps virus-infected Leydig cell cultures completely restores testosterone production. Moreover, we show that gamma interferon-...

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Autors principals: Le Goffic, Ronan, Mouchel, Thomas, Ruffault, Annick, Patard, Jean-Jacques, Jégou, Bernard, Samson, Michel
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC149733/
https://ncbi.nlm.nih.gov/pubmed/12584353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.5.3297-3300.2003
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