Effects of Dipeptide Insertions between Codons 69 and 70 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Primer Unblocking, Deoxynucleoside Triphosphate Inhibition, and DNA Chain Elongation

Finger insertion mutations of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) (T69S mutations followed by various dipeptide insertions) have a multinucleoside resistance phenotype that can be explained by decreased sensitivity to deoxynucleoside triphosphate (dNTP) inhibition...

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Detalhes bibliográficos
Main Authors: Meyer, Peter R., Lennerstrand, Johan, Matsuura, Suzanne E., Larder, Brendan A., Scott, Walter A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC149510/
https://ncbi.nlm.nih.gov/pubmed/12610164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.6.3871-3877.2003
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