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mRNA Instability in the Nucleus Due to a Novel Open Reading Frame Element Is a Major Determinant of the Narrow Tissue Specificity of Folate Receptor α
The folate receptor type α (FR-α) is a promising tumor marker and target. Here, we investigate the mechanistic basis for the tumor specificity and vast overexpression of FR-α. Among representative FR-α-positive (HeLa and JAR) and FR-α-negative (MG63, Caki1, and HT3) cell lines, the transcription rat...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC149483/ https://ncbi.nlm.nih.gov/pubmed/12612090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.6.2202-2212.2003 |
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