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Down-Regulation of Cell Surface Receptors Is Modulated by Polar Residues within the Transmembrane Domain

How recycling receptors are segregated from down-regulated receptors in the endosome is unknown. In previous studies, we demonstrated that substitutions in the transferrin receptor (TR) transmembrane domain (TM) convert the protein from an efficiently recycling receptor to one that is rapidly down r...

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Udgivet i:Mol Biol Cell
Principais autores: Zaliauskiene, Lolita, Kang, Sunghyun, Brouillette, Christie G., Lebowitz, Jacob, Arani, Ramin B., Collawn, James F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Cell Biology 2000
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14946/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10930460/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.11.8.2643
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