Expression of Mutant Glycine Receptors in <i>Xenopus</i> Oocytes Using Canonical and Non-Canonical Amino Acids Reveals Distinct Roles of Conserved Proline Residues

Pentameric ligand-gated ion channels (pLGIC) play important roles in fast neuronal signal transmission. Functional receptors are pentamers, with each subunit having an extracellular domain (ECD), a transmembrane domain (TMD) and an intracellular domain. The binding of the agonist to the ECD induces...

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Autors principals:	Sarah C. R. Lummis, Dennis A. Dougherty
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2022-10-01
Col·lecció:	Membranes
Matèries:	ligand-gated ion channel Cys-loop receptor cis prolyl peptide bond noncanonical amino acid mutagenesis electrophysiology
Accés en línia:	https://www.mdpi.com/2077-0375/12/10/1012
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