Two Domains of the Progesterone Receptor Interact with the Estrogen Receptor and Are Required for Progesterone Activation of the c-Src/Erk Pathway in Mammalian Cells

In breast cancer cells, estrogens activate the Src/Erk pathway through an interaction of the estrogen receptor alpha (ERα) with the SH2 domain of c-Src. Progestins have been reported to activate also this pathway either via an interaction of the progesterone receptor isoform B (PRB) with ERα, which...

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Bibliographische Detailangaben
Hauptverfasser: Ballaré, Cecilia, Uhrig, Markus, Bechtold, Thomas, Sancho, Elena, Di Domenico, Marina, Migliaccio, Antimo, Auricchio, Ferdinando, Beato, Miguel
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Transcriptional Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC149459/
https://ncbi.nlm.nih.gov/pubmed/12612073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.6.1994-2008.2003
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