Hepatocarcinogenic potential of the glucocorticoid antagonist RU486 in B6C3F1 mice: effect on apoptosis, expression of oncogenes and the tumor suppressor gene p53

BACKGROUND: Glucocorticoids inhibit hepatocellular proliferation and modulate the expression of oncogenes and tumor suppressor genes via mechanisms involving the glucocorticoid receptor. Glucocorticoids also produce a receptor-mediated inhibitory effect on both basal and hormone-stimulated expressio...

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Detalles Bibliográficos
Main Authors: Youssef, Jihan A, Badr, Mostafa Z
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2003
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC149417/
https://ncbi.nlm.nih.gov/pubmed/12605714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-2-3
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