Gleevec (STI-571) inhibits lung cancer cell growth (A549) and potentiates the cisplatin effect in vitro

BACKGROUND: Gleevec (aka STI571, Imatinib) is a recently FDA approved anti-tumor drug for chronic myelogenous leukemia. Gleevec binds specifically to BCR-ABL tyrosine kinase and inhibit the tyrosine kinase activity. It cross-reacts with another two important membrane tyrosine kinase receptors, c-kit...

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Bibliografske podrobnosti
Main Authors: Zhang, Peilin, Gao, Wei Yi, Turner, Steven, Ducatman, Barbara S
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2003
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC149413/
https://ncbi.nlm.nih.gov/pubmed/12537587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-2-1
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