MG-132, an inhibitor of proteasomes and calpains, induced inhibition of oocyte maturation and aneuploidy in mouse oocytes

BACKGROUND: Although chromosome missegregation during oocyte maturation (OM) is a significant contributor to human morbidity and mortality, very little is known about the causes and mechanisms of aneuploidy. Several investigators have proposed that temporal perturbations during OM predispose oocytes...

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Bibliographic Details
Main Authors: Mailhes, John B, Hilliard, Colette, Lowery, Mary, London, Steve N
Format: Artigo
Language:Inglês
Published: BioMed Central 2002
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC149371/
https://ncbi.nlm.nih.gov/pubmed/12437781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-9268-1-2
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