Quinolone-DNA Interaction: Sequence-Dependent Binding to Single-Stranded DNA Reflects the Interaction within the Gyrase-DNA Complex

We have investigated the interaction of quinolones with DNA by a number of methods to establish whether a particular binding mode correlates with quinolone potency. The specificities of the quinolone-mediated DNA cleavage reaction of DNA gyrase were compared for a number of quinolones. Two patterns...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Noble, Christian G., Barnard, Faye M., Maxwell, Anthony
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Mechanisms of Action: Physiological Effects
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149327/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12604512/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.3.854-862.2003
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