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Quinolone-DNA Interaction: Sequence-Dependent Binding to Single-Stranded DNA Reflects the Interaction within the Gyrase-DNA Complex

We have investigated the interaction of quinolones with DNA by a number of methods to establish whether a particular binding mode correlates with quinolone potency. The specificities of the quinolone-mediated DNA cleavage reaction of DNA gyrase were compared for a number of quinolones. Two patterns...

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Autors principals: Noble, Christian G., Barnard, Faye M., Maxwell, Anthony
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC149327/
https://ncbi.nlm.nih.gov/pubmed/12604512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.3.854-862.2003
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