Mechanism of Fluoroquinolone Resistance Is an Important Factor in Determining the Antimicrobial Effect of Gemifloxacin against Streptococcus pneumoniae in an In Vitro Pharmacokinetic Model

Antibacterial effect and emergence of resistance to gemifloxacin and levofloxacin were studied in an in vitro pharmacokinetic model of infection. A panel of Streptococcus pneumoniae strains with known mechanisms of resistance were used; two strains had no known resistance mechanism, two had efflux p...

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Bibliographic Details
Main Authors: MacGowan, Alasdair P., Bowker, Karen E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC149284/
https://ncbi.nlm.nih.gov/pubmed/12604547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.3.1096-1100.2003
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