Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line

BACKGROUND: Many tumours undergo disregulation of polyamine homeostasis and upregulation of ornithine decarboxylase (ODC) activity, which can promote carcinogenesis. In animal models of colon carcinogenesis, inhibition of ODC activity by difluoromethylornithine (DFMO) has been shown to reduce the nu...

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Detalhes bibliográficos
Main Authors: Hudson, E Ann, Howells, Lynne M, Gallacher-Horley, Barbara, Fox, Louise H, Gescher, Andreas, Manson, Margaret M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2003
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC149232/
https://ncbi.nlm.nih.gov/pubmed/12525265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-3-2
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