Dephosphorylation of β2-syntrophin and Ca(2+)/µ-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion

Islet cell autoantigen (ICA) 512 is a receptor-tyrosine phosphatase-like protein associated with the secretory granules of neuroendocrine cells, including pancreatic β-cells. Binding of its cytoplasmic tail to β2-syntrophin suggests that ICA512 connects secretory granules to the utrophin complex and...

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Publié dans:	EMBO J
Auteurs principaux:	Ort, Tatiana, Voronov, Sergei, Guo, Jun, Zawalich, Kathleen, Froehner, Stanley C., Zawalich, Walter, Solimena, Michele
Format:	Artigo
Langue:	Inglês
Publié:	Nature Publishing Group 2001
Sujets:	Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149140/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11483505/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.15.4013
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