Enzymatic Assay for Measurement of Intracellular DXG Triphosphate Concentrations in Peripheral Blood Mononuclear Cells from Human Immunodeficiency Virus Type 1-Infected Patients

DXG {[2R-cis]-2-amino-1,9-dihydro-9-[2-[hydroxymethyl]-1,3-dioxolan-4-yl]-6H-purin-6-one} and its prodrug DAPD ([2R-cis]-4-[2,6-diamino-9H-purin-9-yl]-1,3-dioxolane-2-methanol; amdoxovir) are novel 2′,3′-dideoxynucleosides (ddNs) displaying activity against human immunodeficiency virus type 1 (HIV-1...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Kewn, Stephen, Wang, Laurene H., Hoggard, Patrick G., Rousseau, Franck, Hart, Robert, MacNeela, John P., Khoo, Saye H., Back, David J.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 2003
Materias:	Antiviral Agents
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149017/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12499199/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.1.255-261.2003
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