Modeling of Transfer Kinetics at the Serum-Cerebrospinal Fluid Barrier in Rabbits with Experimental Meningitis: Application to Grepafloxacin

The goals of the present study were to model the population kinetics of in vivo influx and efflux processes of grepafloxacin at the serum-cerebrospinal fluid (CSF) barrier and to propose a simulation-based approach to optimize the design of dose-finding trials in the meningitis rabbit model. Twenty-...

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Bibliografiske detaljer
Main Authors: Pfister, Marc, Zhang, Liping, Hammarlund-Udenaes, Margareta, Sheiner, Lewis B., Gerber, Cynthia M., Täuber, Martin G., Cottagnoud, Philippe
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC149016/
https://ncbi.nlm.nih.gov/pubmed/12499181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.1.138-143.2003
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