Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture

A base-modified nucleoside analogue, β-d-N(4)-hydroxycytidine (NHC), was found to have antipestivirus and antihepacivirus activities. This compound inhibited the production of cytopathic bovine viral diarrhea virus (BVDV) RNA in a dose-dependant manner with a 90% effective concentration (EC(90)) of...

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Bibliographic Details
Main Authors: Stuyver, Lieven J., Whitaker, Tony, McBrayer, Tamara R., Hernandez-Santiago, Brenda I., Lostia, Stefania, Tharnish, Phillip M., Ramesh, Mangala, Chu, Chung K., Jordan, Robert, Shi, Junxing, Rachakonda, Suguna, Watanabe, Kyoichi A., Otto, Michael J., Schinazi, Raymond F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC149013/
https://ncbi.nlm.nih.gov/pubmed/12499198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.1.244-254.2003
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