Structure-Activity Relationships for Inhibition of Cysteine Protease Activity and Development of Plasmodium falciparum by Peptidyl Vinyl Sulfones

The Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3 appear to be required for hemoglobin hydrolysis by intraerythrocytic malaria parasites. Previous studies showed that peptidyl vinyl sulfone inhibitors of falcipain-2 blocked the development of P. falciparum in culture and exert...

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Detalhes bibliográficos
Principais autores: Shenai, Bhaskar R., Lee, Belinda J., Alvarez-Hernandez, Alejandro, Chong, Pek Y., Emal, Cory D., Neitz, R. Jeffrey, Roush, William R., Rosenthal, Philip J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC149004/
https://ncbi.nlm.nih.gov/pubmed/12499184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.1.154-160.2003
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