Drug Targeting Mycobacterium tuberculosis Cell Wall Synthesis: Development of a Microtiter Plate-Based Screen for UDP-Galactopyranose Mutase and Identification of an Inhibitor from a Uridine-Based Library

A microtiter plate assay for UDP-galactopyranose mutase, an essential cell wall biosynthetic enzyme of Mycobacterium tuberculosis, was developed. The assay is based on the release of tritiated formaldehyde from UDP-galactofuranose but not UDP-galactopyranose by periodate and was used to identify a u...

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Detalhes bibliográficos
Main Authors: Scherman, Michael S., Winans, Katharine A., Stern, Richard J., Jones, Victoria, Bertozzi, Carolyn R., McNeil, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC148999/
https://ncbi.nlm.nih.gov/pubmed/12499218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.1.378-382.2003
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