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Study of Uridine 5′-Monophosphate (UDP)-Galactopyranose Mutase Using UDP-5-Fluoro-Galactopyranose As a Probe: Incubation Results and Mechanistic Implications

Uridine 5′-monophosphate-5-fluoro-galactopyranose (UDP-5F-Galp, 7) was synthesized and its effect on UDP-Galp mutase (UGM) was investigated. UGM facilitated the hydrolysis of 7 to yield UDP and 5-oxo-galactose (24), but no 11 was detected. (19)F-NMR and trapping experiments demonstrated that the rea...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Org Lett
मुख्य लेखकों: Lin, Geng-Min, Sun, He G., Liu, Hung-wen
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2016
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474323/
https://ncbi.nlm.nih.gov/pubmed/27384425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.6b01618
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