Risk Factors for Selection of the L74I Reverse Transcriptase Mutation in Human Immunodeficiency Virus Type 1-Infected Patients

We analyzed 3,475 human immunodeficiency virus sequences and 241 therapeutic histories. The L74I mutation was carried by 7% of viruses. L74I was strongly associated with T215F, K70R, and V75M/S/T/A mutations and increased with the number of thymidine analog mutations. It seemed to be linked to the u...

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Bibliographische Detailangaben
Hauptverfasser: Wirden, Marc, Roquebert, Bénédicte, Derache, Anne, Simon, Anne, Duvivier, Claudine, Ghosn, Jade, Dominguez, Stephanie, Boutonnet, Véronique, Ait-Arkoub, Zaina, Katlama, Christine, Calvez, Vincent, Marcelin, Anne-Genevieve
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489786/
https://ncbi.nlm.nih.gov/pubmed/16801444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00092-06
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