Activities of Alkoxyalkyl Esters of Cidofovir (CDV), Cyclic CDV, and (S)-9-(3-Hydroxy-2-Phosphonylmethoxypropyl)Adenine against Orthopoxviruses in Cell Monolayers and in Organotypic Cultures

The potencies of several alkoxyalkyl esters of acyclic nucleoside phosphonates against vaccinia virus and cowpox virus were evaluated in cell monolayers and three-dimensional epithelial raft cultures. Prodrugs were at least 20-fold more active than their parent compounds. Octadecycloxyethyl-(S)-9-(3...

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Autores principales: Lebeau, Ilya, Andrei, Graciela, Dal Pozzo, Fabiana, Beadle, James R., Hostetler, Karl Y., De Clercq, Erik, van den Oord, Joost, Snoeck, Robert
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2006
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489770/
https://ncbi.nlm.nih.gov/pubmed/16801436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01489-05
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