Activities of Alkoxyalkyl Esters of Cidofovir (CDV), Cyclic CDV, and (S)-9-(3-Hydroxy-2-Phosphonylmethoxypropyl)Adenine against Orthopoxviruses in Cell Monolayers and in Organotypic Cultures

The potencies of several alkoxyalkyl esters of acyclic nucleoside phosphonates against vaccinia virus and cowpox virus were evaluated in cell monolayers and three-dimensional epithelial raft cultures. Prodrugs were at least 20-fold more active than their parent compounds. Octadecycloxyethyl-(S)-9-(3...

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Autori principali: Lebeau, Ilya, Andrei, Graciela, Dal Pozzo, Fabiana, Beadle, James R., Hostetler, Karl Y., De Clercq, Erik, van den Oord, Joost, Snoeck, Robert
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2006
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489770/
https://ncbi.nlm.nih.gov/pubmed/16801436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01489-05
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