Contribution of the 8-Methoxy Group to the Activity of Gatifloxacin against Type II Topoisomerases of Streptococcus pneumoniae

The inhibitory activities (50% inhibitory concentrations [IC(50)s]) of gatifloxacin and other quinolones against both DNA gyrase and topoisomerase IV of the wild-type Streptococcus pneumoniae IID553 were determined. The IC(50)s of 10 compounds ranged from 4.28 to 582 μg/ml against DNA gyrase and fro...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Kishii, Ryuta, Takei, Masaya, Fukuda, Hideyuki, Hayashi, Katsuhiko, Hosaka, Masaki
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2003
Soggetti:	Mechanisms of Action: Physiological Effects
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148977/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12499172/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.1.77-81.2003
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