gyrA Mutations in Ciprofloxacin-Resistant Bartonella bacilliformis Strains Obtained In Vitro

We isolated and characterized mutants of Bartonella bacilliformis that are resistant to the fluoroquinolone antibiotic ciprofloxacin, which targets the A subunit of DNA gyrase. Mutants had single point mutations in the gyrA gene that changed either Asp-90 to Gly or Asp-95 to Asn and had 3- or 16-fol...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Minnick, Michael F., Wilson, Zachary R., Smitherman, Laura S., Samuels, D. Scott
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148966/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12499219/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.1.383-386.2003
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