Farnesyl Diphosphate Synthase Is a Cytosolic Enzyme in Leishmania major Promastigotes and Its Overexpression Confers Resistance to Risedronate

Farnesyl diphosphate synthase is the most likely molecular target of aminobisphosphonates (e.g., risedronate), a set of compounds that have been shown to have antiprotozoal activity both in vitro and in vivo. This protein, together with other enzymes involved in isoprenoid biosynthesis, is an attrac...

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Bibliographic Details
Main Authors: Ortiz-Gómez, Aurora, Jiménez, Carmen, Estévez, Antonio M., Carrero-Lérida, Juana, Ruiz-Pérez, Luis M., González-Pacanowska, Dolores
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489282/
https://ncbi.nlm.nih.gov/pubmed/16835450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00034-06
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