Disruption of a Nonribosomal Peptide Synthetase in Aspergillus fumigatus Eliminates Gliotoxin Production

The fungal secondary metabolite gliotoxin produced by Aspergillus fumigatus has been hypothesized to be important in the development of invasive aspergillosis. In this study, we addressed this hypothesis by disrupting a nonribosomal peptide synthetase (NRPS) (encoded by gliP) predicted to be involve...

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Detalhes bibliográficos
Main Authors: Cramer, Robert A., Gamcsik, Michael P., Brooking, Rhea M., Najvar, Laura K., Kirkpatrick, William R., Patterson, Thomas F., Balibar, Carl J., Graybill, John R., Perfect, John R., Abraham, Soman N., Steinbach, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489275/
https://ncbi.nlm.nih.gov/pubmed/16757745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00049-06
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