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Bcl2's Flexible Loop Domain Regulates p53 Binding and Survival
p53 not only functions as a transcription factor but also has a direct, apoptogenic role at the mitochondria. We have discovered that DNA damage-induced p53-Bcl2 binding is associated with decreased Bcl2-Bax interaction and increased apoptotic cell death in a mechanism regulated by Bcl2's flexi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1489125/ https://ncbi.nlm.nih.gov/pubmed/16738310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01647-05 |
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