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Bcl2's Flexible Loop Domain Regulates p53 Binding and Survival

p53 not only functions as a transcription factor but also has a direct, apoptogenic role at the mitochondria. We have discovered that DNA damage-induced p53-Bcl2 binding is associated with decreased Bcl2-Bax interaction and increased apoptotic cell death in a mechanism regulated by Bcl2's flexi...

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Bibliografiske detaljer
Main Authors: Deng, Xingming, Gao, Fengqin, Flagg, Tammy, Anderson, Jessica, May, W. Stratford
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489125/
https://ncbi.nlm.nih.gov/pubmed/16738310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01647-05
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