A Nuclear Export Signal and Phosphorylation Regulate Dok1 Subcellular Localization and Functions

Dok1 is believed to be a mainly cytoplasmic adaptor protein which down-regulates mitogen-activated protein kinase activation, inhibits cell proliferation and transformation, and promotes cell spreading and cell migration. Here we show that Dok1 shuttles between the nucleus and cytoplasm. Treatment o...

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Main Authors: Niu, Yamei, Roy, François, Saltel, Frédéric, Andrieu-Soler, Charlotte, Dong, Wen, Chantegrel, Anne-Lise, Accardi, Rosita, Thépot, Amélie, Foiselle, Nadège, Tommasino, Massimo, Jurdic, Pierre, Sylla, Bakary S.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2006
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489083/
https://ncbi.nlm.nih.gov/pubmed/16705178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01817-05
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