Dihydroxythiophenes Are Novel Potent Inhibitors of Human Immunodeficiency Virus Integrase with a Diketo Acid-Like Pharmacophore

We have identified dihydroxythiophenes (DHT) as a novel series of human immunodeficiency virus type 1 (HIV-1) integrase inhibitors with broad antiviral activities against different HIV isolates in vitro. DHT were discovered in a biochemical integrase high-throughput screen searching for inhibitors o...

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Main Authors: Kehlenbeck, S., Betz, U., Birkmann, A., Fast, B., Göller, A. H., Henninger, K., Lowinger, T., Marrero, D., Paessens, A., Paulsen, D., Pevzner, V., Schohe-Loop, R., Tsujishita, H., Welker, R., Kreuter, J., Rübsamen-Waigmann, H., Dittmer, F.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2006
主題:
Vaccines and Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489040/
https://ncbi.nlm.nih.gov/pubmed/16809294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00306-06
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