Hepatitis C Virus Triggers Mitochondrial Permeability Transition with Production of Reactive Oxygen Species, Leading to DNA Damage and STAT3 Activation

Hepatitis C virus (HCV) infection is frequently associated with the development of hepatocellular carcinomas and non-Hodgkin's B-cell lymphomas. Previously, we reported that HCV infection causes cellular DNA damage and mutations, which are mediated by nitric oxide (NO). NO often damages mitocho...

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Detalhes bibliográficos
Main Authors: Machida, Keigo, Cheng, Kevin T.-H., Lai, Chao-Kuen, Jeng, King-Song, Sung, Vicky M.-H., Lai, Michael M. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489016/
https://ncbi.nlm.nih.gov/pubmed/16809325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00321-06
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