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A Highly Restricted T-Cell Receptor Dominates the CD8(+) T-Cell Response to Parvovirus B19 Infection in HLA-A*2402-Positive Individuals

Six of seven HLA-A*2402-positive individuals with acute parvovirus B19 infections made vigorous CD8-positive cytotoxic T-cell (CTL) responses to the viral epitope FYTPLADQF. All responders showed highly focused T-cell receptor (TCR) usage, using almost exclusively BV5.1. The BV5.1 TCR dominated the...

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Detalhes bibliográficos
Main Authors: Kasprowicz, V., Isa, A., Jeffery, K., Broliden, K., Tolfvenstam, T., Klenerman, P., Bowness, P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1488968/
https://ncbi.nlm.nih.gov/pubmed/16775358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02388-05
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