Conditionally Activated E7 Proteins of High-Risk and Low-Risk Human Papillomaviruses Induce S Phase in Postmitotic, Differentiated Human Keratinocytes

The productive program of human papillomaviruses (HPVs) in epithelia is tightly linked to squamous differentiation. The E7 proteins of high-risk HPV genotypes efficiently inactivate the pRB family of proteins that control the cell cycle, triggering S phase in suprabasal keratinocytes. This ability h...

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Autores principales: Banerjee, N. Sanjib, Genovese, Nicholas J., Noya, Francisco, Chien, Wei-Ming, Broker, Thomas R., Chow, Louise T.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2006
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1488939/
https://ncbi.nlm.nih.gov/pubmed/16775338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02499-05
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