Purification of Fully Activated Clostridium botulinum Serotype B Toxin for Treatment of Patients with Dystonia

Clostridium botulinum serotype B toxins 12S and 16S were separated by using a beta-lactose gel column at pH 6.0; toxin 12S passed through the column, whereas toxin 16S bound to the column and eluted with lactose. The fully activated neurotoxin was obtained by applying the trypsin-treated 16S toxin o...

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發表在:	Infect Immun
Principais autores:	Arimitsu, Hideyuki, Inoue, Kaoru, Sakaguchi, Yoshihiko, Lee, Jaechul, Fujinaga, Yukako, Watanabe, Toshihiro, Ohyama, Tohru, Hirst, Robert, Oguma, Keiji
格式:	Artigo
語言:	Inglês
出版:	American Society for Microbiology (ASM) 2003
主題:	Molecular Pathogenesis
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148869/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12595486/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.3.1599-1603.2003
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