Purification of Fully Activated Clostridium botulinum Serotype B Toxin for Treatment of Patients with Dystonia

Clostridium botulinum serotype B toxins 12S and 16S were separated by using a beta-lactose gel column at pH 6.0; toxin 12S passed through the column, whereas toxin 16S bound to the column and eluted with lactose. The fully activated neurotoxin was obtained by applying the trypsin-treated 16S toxin o...

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Detalhes bibliográficos
Main Authors: Arimitsu, Hideyuki, Inoue, Kaoru, Sakaguchi, Yoshihiko, Lee, Jaechul, Fujinaga, Yukako, Watanabe, Toshihiro, Ohyama, Tohru, Hirst, Robert, Oguma, Keiji
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC148869/
https://ncbi.nlm.nih.gov/pubmed/12595486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.3.1599-1603.2003
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