Nuclear Retention of Multiply Spliced HIV-1 RNA in Resting CD4(+) T Cells

HIV-1 latency in resting CD4(+) T cells represents a major barrier to virus eradication in patients on highly active antiretroviral therapy (HAART). We describe here a novel post-transcriptional block in HIV-1 gene expression in resting CD4(+) T cells from patients on HAART. This block involves the...

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Autores principales: Lassen, Kara G, Ramyar, Kasra X, Bailey, Justin R, Zhou, Yan, Siliciano, Robert F
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1487174/
https://ncbi.nlm.nih.gov/pubmed/16839202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.0020068
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