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Design and isolation of ribozyme-substrate pairs using RNase P-based ribozymes containing altered substrate binding sites.

Substrate recognition and cleavage by the bacterial RNase P RNA requires two domains, a specificity domain, or S-domain, and a catalytic domain, or C-domain. The S-domain binds the T stem-loop region in a pre-tRNA substrate to confer specificity for tRNA substrates. In this work, the entire S-domain...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Mobley, E M, Pan, T
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 1999
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC148707/
https://ncbi.nlm.nih.gov/pubmed/10518624
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