Design and isolation of ribozyme-substrate pairs using RNase P-based ribozymes containing altered substrate binding sites.
Substrate recognition and cleavage by the bacterial RNase P RNA requires two domains, a specificity domain, or S-domain, and a catalytic domain, or C-domain. The S-domain binds the T stem-loop region in a pre-tRNA substrate to confer specificity for tRNA substrates. In this work, the entire S-domain...
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| Опубликовано в:: | Nucleic Acids Res |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
1999
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148707/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10518624/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.21.4298 |
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