Gene activation by triplex-forming oligonucleotide coupled to the activating domain of protein VP16.

Triplex-forming oligonucleotides (TFOs) are generally designed to inhibit transcription or DNA replication but can be used for more diverse purposes. Here we have designed a chimera peptide-TFO able to activate transcription from a target gene. The designed hybrid molecule contains a triplex-forming...

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Auteurs principaux: Kuznetsova, S, Ait-Si-Ali, S, Nagibneva, I, Troalen, F, Le Villain, J P, Harel-Bellan, A, Svinarchuk, F
Format: Artigo
Langue:Inglês
Publié: 1999
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Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC148666/
https://ncbi.nlm.nih.gov/pubmed/10497263
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