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Gene activation by triplex-forming oligonucleotide coupled to the activating domain of protein VP16.

Triplex-forming oligonucleotides (TFOs) are generally designed to inhibit transcription or DNA replication but can be used for more diverse purposes. Here we have designed a chimera peptide-TFO able to activate transcription from a target gene. The designed hybrid molecule contains a triplex-forming...

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Udgivet i:Nucleic Acids Res
Principais autores: Kuznetsova, S, Ait-Si-Ali, S, Nagibneva, I, Troalen, F, Le Villain, J P, Harel-Bellan, A, Svinarchuk, F
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1999
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148666/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10497263/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.20.3995
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